AQA GCSE · Question 08.2 · Homeostasis and Response
The kidneys have an important role in homeostasis. Describe what happens to glucose, protein and urea in the kidneys.
How to approach this question
Structure your answer by considering the three main processes in the nephron: filtration, selective reabsorption, and excretion. For each substance (glucose, protein, urea), describe how it is treated at each stage.
Full Answer
The kidneys filter blood and produce urine in a three-step process occurring in millions of tiny tubes called nephrons.
- **Glucose:** Glucose is a small molecule, so it is easily filtered out of the blood in the glomerulus and enters the kidney tubule. However, glucose is a valuable source of energy for the body, so it needs to be conserved. All of the filtered glucose is reabsorbed back into the bloodstream from the tubule by the process of active transport. Therefore, there should be no glucose in the urine of a healthy person.
- **Protein:** Proteins are very large molecules. During filtration in the glomerulus, they are too big to be forced through the filter and into the Bowman's capsule. They remain in the blood. Consequently, there should be no protein in the urine of a healthy person.
- **Urea:** Urea is a small waste molecule produced in the liver from the breakdown of excess amino acids. Like glucose, it is small enough to be filtered out of the blood into the kidney tubule. However, unlike glucose, it is a waste product that the body needs to remove. Very little urea is reabsorbed; most of it remains in the filtrate and becomes a major component of urine, which is then excreted.
Common mistakes
✗ Confusing filtration and reabsorption.
✗ Stating that protein is filtered and then reabsorbed.
✗ Stating that glucose is excreted in urine (this only happens in people with untreated diabetes).
✗ Forgetting to mention that urea is a waste product.